Dihexa

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Cognitive & NeuroprotectivePreclinicalOralSubcutaneousIntranasal

An angiotensin IV analog reported to be 10 million times more potent than BDNF at promoting new synapse formation. Under investigation for cognitive disorders.

Molecular Weight

507.6 Da

Half-Life

~12 hours

Sequence

Hexanoyl-Tyr-Ile-Ahx-NH2

Mechanism of Action

Binds HGF (hepatocyte growth factor) receptor c-Met, promoting synaptogenesis, neuronal connectivity, and dendritic spine formation.

Dosing Protocol

Oral: 10-20 mg daily. Subcutaneous: 1-5 mg. Intranasal protocols vary. Very limited human dosing data.

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Reconstitution

Oral compound or dissolved in solution for injection.

Storage

Room temperature, dry. Solutions: 2-8°C.

Side Effects

●Very limited human safety data
●Potential for excessive growth factor stimulation

Key Research Findings

●Reversed cognitive deficits in scopolamine-treated rats
●10^7 times more potent than BDNF at synaptogenesis in vitro
●Restored cognitive function in aged rats to youthful levels

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.