GHK (without copper)

Also known as: Glycyl-Histidyl-Lysine, Liver Cell Growth Factor

Longevity / Anti-AgingResearch compound / CosmeceuticalTopicalSubcutaneous

The base tripeptide that can chelate copper. When copper-free, still shows gene-resetting properties, resetting ~4,000 genes toward a healthier expression pattern.

Molecular Weight

340.4 Da

Half-Life

~2-4 hours

Sequence

Gly-His-Lys

Mechanism of Action

Broad gene regulation: upregulates collagen, anti-cancer genes, and antioxidant systems while suppressing inflammatory and metastasis-related genes. Resets gene expression toward youthful patterns.

Dosing Protocol

Topical: 1-2% formulation daily. Injectable: 100-200 mcg subcutaneous.

Open peptide calculator

Reconstitution

Various formulations. 5mg vial + 2mL BAC water for injectable.

Storage

Lyophilized: -20°C. Solutions: 2-8°C.

Side Effects

●Very well-tolerated
●Mild injection site reactions

Key Research Findings

●Resets expression of 4,000+ genes toward healthy patterns (Genome Biology 2012)
●Upregulates 31 collagen genes and multiple DNA repair genes
●Suppresses fibronectin, TGF-beta, and metastasis-related genes

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.