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GHK-Cu

Also known as: Copper Peptide, Glycyl-L-histidyl-L-lysine:copper(II)

Skin & HairResearch compound / CosmeceuticalTopicalSubcutaneousMicroneedling

A naturally occurring copper tripeptide found in human plasma, saliva, and urine. Declines with age. Studied for skin rejuvenation, wound healing, and hair growth.

Molecular Weight

403.9 Da

Half-Life

~12 hours (topical), ~1 hour (injected)

Sequence

GHK + Cu²⁺

Mechanism of Action

Stimulates collagen I, III, and V synthesis, upregulates glycosaminoglycans and decorin, promotes angiogenesis, and has antioxidant and anti-inflammatory effects.

Dosing Protocol

Topical: 1-2% cream applied daily. Injectable: 50-200 mcg subcutaneous near target area.

Open peptide calculator
Reconstitution

50mg vial + 2mL BAC water = 25mg/mL (25,000 mcg/mL). Use very small volumes.

Storage

Protect from light. Lyophilized: -20°C. Solutions: 2-8°C.

Side Effects
  • ●Skin irritation (topical)
  • ●Mild redness at injection site
Key Research Findings
  • ●Increased collagen production by 70% in skin studies
  • ●Stimulated hair follicle growth in alopecia models
  • ●Reduced skin inflammation markers

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.