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Humanin

Also known as: HN, HNG (S14G variant)

Longevity / Anti-AgingPreclinicalSubcutaneousIntravenous

A mitochondria-derived peptide with cytoprotective effects. Protects against oxidative stress, apoptosis, and neurodegenerative processes. Declines with age.

Molecular Weight

2687.2 Da

Half-Life

~30 minutes (HNG variant more stable)

Sequence

MAPRGFSCLLLLTSEIDLPVKRRA

Mechanism of Action

Binds IGFBP-3 and BAX to inhibit apoptosis. Activates STAT3 and ERK signaling for cell survival. Enhances mitochondrial function and reduces oxidative stress.

Dosing Protocol

HNG (potent analog): 1-4 mg subcutaneous daily. Research protocols vary.

Open peptide calculator
Reconstitution

5mg vial + 2mL BAC water.

Storage

Lyophilized: -20°C. Reconstituted: 2-8°C.

Side Effects
  • ●Generally well-tolerated in animal studies
  • ●Limited human safety data
Key Research Findings
  • ●Neuroprotective against Alzheimer's-associated amyloid-beta toxicity
  • ●Improved glucose metabolism and insulin sensitivity
  • ●Higher circulating levels correlate with longevity in centenarians

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.