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KPV

Also known as: Lys-Pro-Val, Alpha-MSH fragment

Immune SystemExperimentalOralSubcutaneousTopical

A C-terminal tripeptide fragment of alpha-MSH with potent anti-inflammatory properties. Being studied for gut inflammation, IBD, and skin conditions.

Molecular Weight

342.4 Da

Half-Life

~2-4 hours

Sequence

Lys-Pro-Val

Mechanism of Action

Enters cells and directly inhibits NF-kB nuclear translocation, suppressing inflammatory cytokine production. Does not require melanocortin receptor binding for anti-inflammatory effect.

Dosing Protocol

Oral: 200-500 mcg daily (BPC capsules for gut). Subcutaneous: 100-500 mcg daily.

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Reconstitution

Available as oral capsules or injectable. 5mg vial + 2mL BAC water.

Storage

Room temperature (capsules). Lyophilized: -20°C.

Side Effects
  • ●Generally very well-tolerated
  • ●Minimal reported side effects
Key Research Findings
  • ●Reduced colonic inflammation in IBD animal models
  • ●Direct NF-kB inhibition without receptor-dependent signaling
  • ●Accelerated wound healing and reduced skin inflammation

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.