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MOTS-c

Also known as: Mitochondrial ORF of the 12S rRNA Type-c

Metabolic & PerformanceExperimentalSubcutaneous

A mitochondria-derived peptide that regulates metabolic homeostasis. Acts as an exercise mimetic, improving insulin sensitivity and fat metabolism.

Molecular Weight

2174.6 Da

Half-Life

~15 hours

Sequence

MRWQEMGYIFYPRKLR

Mechanism of Action

Activates AMPK pathway, enhances glucose uptake in skeletal muscle, promotes fatty acid oxidation, and regulates the folate-methionine cycle in the nucleus.

Dosing Protocol

5-10 mg subcutaneous 3-5x per week. Often used in 4-8 week cycles.

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Reconstitution

5mg vial + 1mL BAC water = 5000 mcg/mL.

Storage

Lyophilized: -20°C. Reconstituted: 2-8°C.

Side Effects
  • ●Injection site irritation
  • ●Mild fatigue initially
  • ●Generally well-tolerated
Key Research Findings
  • ●Improved insulin sensitivity and glucose metabolism in obese mice
  • ●Exercise-mimetic properties via AMPK activation
  • ●Reduced diet-induced obesity and insulin resistance in animal models

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.