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NAD+

Also known as: Nicotinamide Adenine Dinucleotide, NAD IV

Longevity / Anti-AgingSupplement / Research compoundIntravenousSubcutaneousOral (precursors)

A critical coenzyme found in every cell, involved in energy metabolism, DNA repair, and sirtuin activation. Declines significantly with age.

Molecular Weight

663.4 Da

Half-Life

~1-4 hours (IV), variable (oral precursors)

Sequence

Dinucleotide (not a peptide — coenzyme)

Mechanism of Action

Serves as electron carrier in mitochondrial energy production. Activates sirtuins (SIRT1-7) for DNA repair and gene regulation. Substrate for PARP enzymes in DNA damage response.

Dosing Protocol

IV: 250-1000mg infused over 2-4 hours. Subcutaneous: 50-100mg daily. Oral precursors (NMN/NR): 250-1000mg daily.

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Reconstitution

100mg vial + 3mL BAC water for subcutaneous. IV supplied pre-mixed.

Storage

Protect from light. Lyophilized: -20°C. Solutions: 2-8°C.

Side Effects
  • ●Nausea
  • ●Flushing
  • ●Chest pressure (IV)
  • ●Headache
  • ●Cramping during infusion
Key Research Findings
  • ●NAD+ levels decline 50% between ages 40-60
  • ●NMN supplementation reversed age-related arterial dysfunction in mice
  • ●Sirtuin activation linked to improved healthspan in multiple models

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.