Pentosan Polysulfate

Also known as: PPS, Elmiron, Cartrophen

Healing & RecoveryFDA Approved (interstitial cystitis)OralSubcutaneousIntramuscular

A semi-synthetic heparinoid compound used for interstitial cystitis and being studied for osteoarthritis. Provides glycosaminoglycan layer restoration and anti-inflammatory effects.

Molecular Weight

4000-6000 Da (average)

Half-Life

~24 hours

Sequence

Semi-synthetic polysulfated xylan (not a peptide)

Mechanism of Action

Restores the glycosaminoglycan layer of the bladder epithelium. Anti-inflammatory, anti-coagulant, and fibrinolytic properties. Promotes cartilage matrix synthesis in joints.

Dosing Protocol

Oral: 100mg 3x daily (FDA dosing). Injectable: 3mg/kg subcutaneous twice weekly for osteoarthritis.

Open peptide calculator

Reconstitution

Injectable: supplied pre-mixed. Oral: capsules.

Storage

Room temperature.

Side Effects

●GI upset
●Headache
●Hair loss (rare, oral)
●Rare maculopathy with long-term use

Key Research Findings

●FDA-approved for interstitial cystitis pain relief
●Improved joint function in osteoarthritis clinical trials (injectable)
●Promoted cartilage regeneration in animal models

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.