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Semaglutide

Also known as: Ozempic, Wegovy, Rybelsus

GLP-1 / Weight LossFDA ApprovedSubcutaneousOral

A GLP-1 receptor agonist used for type 2 diabetes and weight management. One of the most studied peptides for metabolic health.

Molecular Weight

4113.6 Da

Half-Life

~7 days

Sequence

Modified GLP-1 analog (31 amino acids)

Mechanism of Action

Mimics GLP-1 hormone, stimulating insulin secretion, suppressing glucagon, slowing gastric emptying, and promoting satiety via hypothalamic signaling.

Dosing Protocol

Titration schedule: Start 0.25mg/week for 4 weeks, increase to 0.5mg, then 1mg, up to 2.4mg/week for weight management.

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Reconstitution

Typically supplied pre-mixed. Research-grade: 5mg vial + 2mL BAC water.

Storage

Refrigerate 2-8°C. Do not freeze. Protect from light.

Side Effects
  • ●Nausea
  • ●Vomiting
  • ●Diarrhea
  • ●Constipation
  • ●Abdominal pain
Key Research Findings
  • ●STEP trials: 15-17% body weight reduction
  • ●SELECT trial: 20% cardiovascular risk reduction
  • ●Significant HbA1c reduction in diabetes management

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.