Back to database

Semax

Also known as: MEHFPGP

Cognitive & NeuroprotectiveApproved in Russia/UkraineIntranasalSubcutaneous

A synthetic analog of ACTH(4-7) with neuroprotective and cognitive-enhancing properties. Used for stroke recovery and cognitive disorders.

Molecular Weight

813.9 Da

Half-Life

~3-5 minutes (effects last hours)

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro

Mechanism of Action

Upregulates BDNF and NGF expression, modulates serotonin and dopamine systems, enhances neuroplasticity, and has anti-inflammatory effects in the CNS.

Dosing Protocol

Intranasal: 200-600 mcg per nostril, 2-3x daily. Injectable: 500 mcg subcutaneous daily.

Open peptide calculator
Reconstitution

5mg vial + 2mL BAC water = 2500 mcg/mL.

Storage

Lyophilized: -20°C. Reconstituted: 2-8°C.

Side Effects
  • ●Mild headache
  • ●Nasal dryness
Key Research Findings
  • ●Improved cognitive function post-stroke in clinical trials
  • ●Increased BDNF expression by 1.4x in hippocampus
  • ●Neuroprotective against oxidative stress

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.