VIP

Also known as: Vasoactive Intestinal Peptide, Aviptadil

Immune SystemInvestigational (multiple indications)IntravenousSubcutaneousIntranasal

A 28-amino acid neuropeptide with potent anti-inflammatory, immunomodulatory, and vasodilatory properties. Being studied for CIRS, pulmonary conditions, and autoimmune diseases.

Molecular Weight

3326.8 Da

Half-Life

~1-2 minutes (rapid degradation)

Sequence

HSDAVFTDNYTRLRKQMAVKKYLNSILN

Mechanism of Action

Binds VPAC1/VPAC2 receptors, suppressing TNF-alpha, IL-6, and NF-kB pathways. Promotes regulatory T-cells, enhances surfactant production in lungs, and dilates blood vessels.

Dosing Protocol

Intranasal: 50 mcg per nostril 4x daily (Shoemaker CIRS protocol). IV: clinical trial doses vary.

Open peptide calculator

Reconstitution

Typically supplied pre-mixed for intranasal use.

Storage

Refrigerate 2-8°C. Very sensitive to degradation.

Side Effects

●Nasal congestion
●Diarrhea
●Hypotension (IV)
●Flushing

Key Research Findings

●Improved pulmonary function in COVID-19 ARDS (Aviptadil trials)
●Reduced inflammatory markers in CIRS/mold illness protocols
●Neuroprotective effects in neurodegenerative disease models

Research Use Only

This information is provided for educational and research purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional before using any research compounds.